Researchers use AI to design proteins that cut up other proteins
AI design tools make proteins that break bonds that are stable for hundreds of years.
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The zinc project was a bit more complicated. They tested many designs that didn’t include the water molecule that normally takes part in that reaction. These had a relatively low success rate, with only 14 out of 89 showing weak catalytic activity. When they modeled the ones that didn’t work, they found that the designs often let a water molecule block the site where reactions should take place.
So, they also tried designs where they placed a water molecule in the right location as an additional design constraint. These had a much higher success rate, with 35 out of 38 showing some catalytic…
