NFL Week 6 upset alert: Can Titans beat TD-favorite Colts? Will rested Bucs upset Steelers?
These favorites are not only at risk of not covering, but they could lose outright in Week 6
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No matter what you think going into a given contest, the beautiful thing about the NFL is that it largely doesn't matter once the game kicks off. At that point, anything can happen, which is why the league has us in a chokehold throughout the fall.
That said, as we roll along in a given season, the schedule begins to dictate where upsets could occur, simply due to the fact that one team may be a little more rested than the other, particularly as bye weeks come into play.